PCOS is associated with poorer health, with increased medication use

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Women with polycystic ovary syndrome had poorer health conditions, more frequent use of medications, and poorer health than women without the disease, according to a population-based Finnish study.

“I have been working with PCOS for over 20 years and this time instead of labeling PCOS as a sterility problem, I have seen evidence that PCOS is emerging as a health risk.” Terhi T. Piltonen, MD, Healio told OB / GYN and a reproductive medicine consultant and a clinical researcher at the University of Oulu in Finland.

Data derived from Kujanpää L, et al. Acta Obstet Gynecol Scand. 2022; doi: 10.1111 / aogs.14382.

Pilton and colleagues used data from the 1966 Northern Finland Birth Cohort at age 31 to diagnose oligomenorrhea, amenorrhea, and hirsutism, or diagnose PCOS at age 46 among 246 women and 1,573 women with no symptoms or no diagnosis of PCOS. At 46 years old.

Participants were informed of their diagnoses and symptoms, overall health status, use of medications, and use of health services through 46-year-old questionnaires.

Health status

A higher proportion of women with PCOS reported hypertension (30.4% vs. 17.9%); Type 2 diabetes (6.7% vs. 2.2%); depression (20.5% vs. 14%); migraine (34.2% vs. 24.7%); osteoarthritis of the knee, back or shoulder (26.8% vs. 18.1%); fractures (24.5% vs. 16.8%); gestational diabetes (30.2% vs. 25.1%); compared with women without preeclampsia (15.5% vs. 8.7%) and endometriosis (13.4% vs. 8.4%).

Adjustments for BMI, physical activity, education, marital status, alcohol consumption, and smoking revealed that women with PCOS had hypertension (adjusted OR = 1.76; 95% CI, 1.27-2.44), any osteoarthritis (aOR = 1, 66); 95% CI, 1.2-2.29), migraine (aOR = 1.58; 95% CI, 1.17-2.13), tendinitis (aOR = 1.81; 95% CI, 1.22- 2.68) and endometriosis (aOR = 1.81; 95.9% CI, 1.11). -2.76).

Women with PCOS were also more likely to develop autoimmune diseases, such as joint pain (aOR = 1.46; 95% CI, 1.1-1.94) and joint inflammation (aOR = 1.49; 95% CI, 1). , 05-2,11) – and repetitive upper respiration. tract infections and symptoms – such as multiple incidence of pneumonia (aOR = 1.91; 95% CI, 1.28-2.86) and other people who may be infected (aOR = 2.13; 95% CI, 1.28 -3.54).

In general, women with PCOS were at higher risk of dying than their peers, even when adjusted for disorder (RR = 1.37; 95% CI, 1.17-1.6). Specifically, women with PCOS were more likely to have five or more comorbidities than their peers, and women without PCOS were less likely to have three comorbidities.

Medications, health services

In general, women with PCOS had a higher risk of using the medication than those without the disorder (RR = 1.27; 95% CI, 1.08–1.5). In particular, they were grouped together as “food tract and metabolism,” “dermatological,” “not only sex hormones and insulin but also systemic hormone preparations,” and “nervous system,” according to the study.

Despite the increased risk of disease, symptoms, and medication use in women with PCOS, there was no significant difference in the number of visits to health care providers among women with and without PCOS (OR = 1.18; 95% CI, 0.998-1.393).

Piltonen said that PCOS should be diagnosed early, which means that diagnostic criteria and tools should be well accepted, accepted, and accepted in clinical practice.

In addition to developing these tools, Piltonen said researchers need to evaluate the impact of PCOS after menopause.

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