Increased fish consumption may be linked to an increased risk of melanoma – ScienceDaily

Eating higher levels of fish, including tuna and fried fish, is associated with a higher risk of developing malignant melanoma, a large U.S. adult study suggests. Causes and control of cancer.

Eunyoung Cho, the lead author, said: “Melanoma is the fifth most common cancer in the United States and the risk of developing melanoma in a lifetime is one in 38 for whites, one in 1,000 for blacks and 167 for Hispanics.1. Although fish intake has increased in the US and Europe in recent decades, the results of previous studies investigating the link between fish intake and melanoma risk are inconsistent. Our findings have identified an association that needs further research. “

Researchers at Brown University (USA) found that the median daily fish consumption was 3.2 grams, the risk of malignant melanoma was 22% higher than the median daily consumption of 42.8 grams. They also found that those with a median daily intake of 42.8 grams of fish had a 28% higher risk of developing abnormal cells in the outer layer of the skin alone – known as stage 0 melanoma or melanoma in situ – compared to those with a median. the daily intake was 3.2 grams of fish. A portion of the fish is cooked to approximately 140 grams of fish.

To study the relationship between fish intake and melanoma risk, the authors analyzed data collected from 491,367 adults who were hired from across the U.S. for the NIH-AARP Diet and Health Study between 1995 and 1996. Participants, who were on average 62 years old, reported how often they ate fried fish, non-fried fish and tuna the previous year, and reported the size of their portions.

Researchers have calculated the incidence of new melanomas that have developed over an average of 15 years using data obtained from cancer records. Socio-demographic factors were taken into account, as well as participants ’BMI, level of physical activity, smoking history, daily alcohol consumption, caffeine and calories, family history of cancer, and average local UV radiation. 5,034 participants (1.0%) developed malignant melanoma during the study period and 3,284 (0.7%) developed stage 0 melanoma.

The researchers found that higher intake of non-fried fish and tuna was associated with malignant melanoma and a higher risk of developing stage 0 melanoma. Those with a median daily tuna consumption of 14.2 grams had a 20% higher risk of malignant melanoma and a 17% higher risk of stage 0 melanoma compared with a median daily consumption of 0.3 grams. The median daily consumption of uncooked fish was 17.8 grams with an 18% higher risk of malignant melanoma and a 25% higher risk of stage 0 melanoma compared with a median of 0.3 grams per day of uncooked fish. . Researchers have not identified a significant relationship between consuming fried fish and the risk of malignant melanoma or phase 0 melanoma.

Eunyoung Chok said: “We believe that our findings may be attributed to fish contaminants such as polychlorinated biphenyls, dioxins, arsenic and mercury. the concentrations of these contaminants in the bodies of the participants and therefore further research are needed to confirm this relationship ”.

The researchers noted that the observational nature of the study did not reveal any causal implications for fish intake and the risk of melanoma. They also did not take into account some of the risk factors for melanoma, such as the number of moles, hair color, a history of severe sunburn, and sun-related behaviors in their analyzes. In addition, since the average daily fish intake was calculated at the beginning of the study, it may not be indicative of the dietary life of the participants.

The authors suggest that future research is needed to investigate the components of fish that may contribute to the observed link between fish intake and melanoma risk and the underlying biological mechanisms. At the moment, they do not recommend any changes in fish consumption.

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